It’s four days after the latest presidential election, and Marc Kadella has the post-election blues. Sure, his guy didn’t win, but there’s more to it than that: the defeated incumbent was a decent man. Too bad you can’t say the same for his Machiavellian opponent—or his photogenic partner-in-crime. Thomas Jefferson Carver is charming and energetic, with a former beauty queen for a wife—and a name for the job to boot. Together they’re the package deal: young, modern, forward-thinking, and successful. That Mr. Carver was often accused of womanizing and that the couple used political clout to line their own pockets didn’t seem to matter to the American electorate.
After a mysterious outbreak of a highly lethal virus ravages the globe and hundreds succumb to the contagious illness, the U.S government instigates a cordon sanitaire in major cities to contain it from spreading rapidly around the nation. At the onset of the epidemic, his ex-wife, Kate, an epidemiologist for the CDC, warns Frank and their daughter, Ella to prepare for the worst. The only hope of survival is retreating to their cottage on one of the isolated islands in the St. Lawrence River. Easy for Frank, he’s already there but when his daughter suffers a major setback, Frank is forced out of his comfort zone.